NFL Best Bets: Week 10 Picks, Predictions & Odds To Consider

2021 Week 1: NFL Best Bets

We went 3-2 with our bets last week, but because we placed twice as many units on the Chargers-Eagles game, we came away with +2 units last Sunday.

Can't complain about making money. Hopefully, you are following our advice, as we are now 12-8 over the last four weeks.

Week 9 was a wild ride full of crazy upsets. The Bills lost to the Jaguars 9-6, the Dallas Cowboys were dominated by the Denver Broncos, Cleveland defeated their AFC North rivals in the Cincinnati Bengals, the New York Giants escaped with a victory over the Las Vegas Raiders, the Saints lost on a last-second field goal to the Atlanta Falcons, and the Rams were outplayed by the Tennessee Titans on Sunday Night Football despite the absence of Derrick Henry.

If you thought we would get a return to normalcy in Week 10, you were very much wrong as the Baltimore Ravens got spanked by the Miami Dolphins in primetime on Thursday Night Football. As the postseason picture begins to become more clear, it's time to gear up for this week's edition of NFL best bets. It takes a lot of energy and research to have success over the course of a season when it comes to sports betting. Here at FantasySP, we are committed to helping you cash. Remember, if you win 55% of your bets, you are a really good gambler. We are looking at some eye opening odds this week and will help you decipher the best games to place your money on, whether it's moneylines, over-unders, or prop bets. With that, let's dive in.

Learn more about our fantasy football tools and products!

WEEK 10 NFL BEST BETS

Kansas City Chiefs at Las Vegas Raiders (+2.5)

What in the world is going on in Kansas City? The Chiefs barely escaped against the Giants in Week 8, and almost lost to a Green Bay Packers team that was missing MVP candidate Aaron Rodgers in Week 9. Although Kansas City is coming off back-to-back victories, the team is not performing at a high level. The offense is what is most concerning as Patrick Mahomes has been somewhat careless with the football, and Tyreek Hill has had to really struggle for every single yard. Kansas City only posted 13 points against a Packers secondary missing their two best corners in Jaire Alexander and Eric Stokes. That said, I think this is a get-right game for Mahomes and the offense. The defense has actually played pretty well as of late, allowing just 16 points per game over their last four contests, in which the team has a 3-1 record.

As of the publication of this article, 64% of bets on the spread have been in favor of the Chiefs. But more importantly, 76% of the money is on the Chiefs. That means that professional gamblers are placing large sums on Mahomes to get it together in Vegas this Sunday. With an over/under of 52 points, we are likely looking at a high-scoring affair. Look for Mahomes to eclipse 300 yards and find both Hill and Travis Kelce for touchdowns.

The Pick: Chiefs (-2.5)

Prediction: 31-23 Chiefs

Bonus Bet: Over 52 points

Cleveland Browns at New England Patriots (-2.5)

Cleveland will be without the services of Nick Chubb, who is coming off a huge 137-yard performance with two trips to the end zone. Kareem Hunt is still on Injured Reserve and Odell Beckham Jr. has been waived and claimed by the Los Angeles Rams. While the Beckham news might actually be good for Baker Mayfield and the Browns, Cleveland is a run-first offense and will have to rely on D'Ernest Johnson. Even Demetric Felton and John Kelly have been ruled out with COVID-19, so Johnson's backup running back is still unclear up to this point. Johnson could be the only healthy running back ready to suit up.

Meanwhile, New England has dominated the Browns in Foxborough over the last 30 years. The last time that the Browns defeated the Patriots in Foxborough was back in 1992. Although only 47% of bets are on the Patriots against the spread, a whopping 67% of the money is backing New England even as 2.5-point favorites. The high-stakes professionals clearly believe in rookie Mac Jones and Bill Belichick. New England may have running back concerns of their own as Damien Harris and rookie Rhamondre Stevenson are still in the concussion protocol and are unlikely to suit up on Sunday. However, Brandon Bolden and J.J. Taylor have proven to be fairly efficient. New England's defense has been playing great defense and I think this is the game where Mac Jones proves he is here to stay in the NFL. This one will come down to the wire, but I'm expecting New England to barely cover.

Pick: Patriots (-2.5)

Prediction: 27-24 Patriots

Atlanta Falcons at Dallas Cowboys (-9)

The Cowboys were essentially blanked by the Denver Broncos last week before scoring two late garbage-time touchdowns to make the score somewhat respectable. After losing money on the Cowboys last week, I'm going back to the well. I think this is the perfect opportunity for Dak Prescott to air it out against an Atlanta Falcons secondary that has struggled all season long. CeeDee Lamb is going to have his best game of the season against the team that passed on him in the NFL Draft.

While the Falcons are coming off a huge victory over the Saints, I don't think Matt Ryan will be able to keep up with Dallas' potent offense. Without Calvin Ridley, his only real weapons are rookie tight end Kyle Pitts, and perhaps the best story of the year in Cordarrelle Patterson. Did you know that Patterson has more scrimmage yards than Dalvin Cook, more receptions than DeAndre Hopkins, more touchdowns than Travis Kelce, and more yards per catch than Tyreek Hill? Yeah, I didn't think so. Still, it will take the Falcons playing at their very best to keep up with Prescott, Zeke, Lamb, and Amari Cooper, plus an offensive line that is anchored by Tyron Smith. Dallas is 8-2 against the spread in their last 10 games dating back to last season. Look for them to increase that number to 9-2.

Pick: Cowboys (-9)

Prediction: 34-21 Cowboys

Bonus: Lamb OVER yards and receptions

Tampa Bay Buccaneers at Washington Football Team (+9.5)

The only team that came somewhat close to ending Tom Brady's quest for a Super Bowl in his debut season with the Bucs was Washington. Taylor Heinicke did a remarkable job in the Wild Card game last season, and he'll get another chance in Week 10. It looks like the Bucs could be without the services of Chris Godwin. If so, I think it's very hard to pass on taking Washington and the points. Even if Godwin plays, Heinicke has played well in Ryan Fitzpatrick's absence, and tight end Logan Thomas is expected to make his long-awaited return. Call it a gut feeling, but I think Chase Young forces a sack-fumble that Washington takes back to the house. Still, Tampa should win this game, but I am very comfortable betting on Washington against the spread. Consider a parlay with the over as well. After all, Washington has been allowing the most points per game to opposing teams and Tom Brady will look to get back on track after losing to the Saints in Week 8 before Tampa's bye week.

Pick: Football Team (+9.5)

Prediction: 31-27 Buccaneers

Bonus: Over 51 points

Minnesota Vikings at Los Angeles Chargers (-3.5)

Has any team played in as many one-possession contests as the Vikings? No. The question is whether the Vikings will be able to win this game outright on the road or at least cover the spread. Minnesota is 7-3 in their last 10 games as road underdogs. Considering Dalvin Cook will still be suiting up despite the domestic abuse rumors swirling around that locker room, I expect Minnesota to try to slow the game down and keep the ball out of Justin Herbert's hands as much as possible by giving Cook the rock. Minnesota has said they are going to throw the ball more, and they should with Justin Jefferson and Adam Thielen catching passes from Kirk Cousins, but it's hard not to give one of the best running backs in the league the ball 25 times per game. The Chargers' defense has been very generous to opposing running backs so Cook should steamroll Joey Bosa and the Los Angeles defensive line. While I think the Chargers still escape with a victory, Los Angeles will need a game-winning field goal to get the victory.

Pick: Vikings (+3.5)

Prediction: 27-24 Chargers

Terms & Conditions: 21+ and present in CO, IA, IL, IN, MI, NJ, PA, TN, VA or WV. New users only. Must wager in designated offer market. $10 first deposit required. $150 max bonus. See full terms at sportsbook.fanduel.com. Gambling Problem? Call: 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN), 1-800-270-7117 for confidential help (MI), 1-800-GAMBLER (NJ, PA, IL, VA), TN REDLINE 1-800-889-9789 (TN), or visit www.1800gambler.net (WV).